Water soluble polymers in tumor targeted delivery.
نویسندگان
چکیده
The rationales for the use of water soluble polymers for anticancer drug delivery include: the potential to overcome some forms of multidrug resistance, preferential accumulation in solid tumors due to enhanced permeability and retention (EPR) effect, biorecognizability, and targetability. The utility of a novel paradigm for the treatment of ovarian carcinoma in an experimental animal model, which combines chemotherapy and photodynamic therapy with polymer-bound anticancer drugs is explained. Research and clinical applications as well as directions for the future development of macromolecular therapeutics are discussed.
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عنوان ژورنال:
- Journal of controlled release : official journal of the Controlled Release Society
دوره 74 1-3 شماره
صفحات -
تاریخ انتشار 2001